Both MEAN and MERN stacks leverage Node.js for server-side operations, enabling scalable and efficient execution of JavaScript beyond the confines of the browser. While MEAN excels in handling complex applications with Angular's rich feature set, MERN prioritizes flexibility and simplicity through React's approach. Ultimately, the decision between MEAN and MERN hinges on project requirements, developer expertise, and preferences regarding comprehensive frameworks versus streamlined libraries. MEAN Stack Vs MERN Stack are both formidable options, offering developers a rich toolkit to build cutting-edge web applications.